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????????? ?첸???? ????? ??? ?????? ?????? ?筠??? 9??????? ???? ?????? ??????? ?????? ?????? ??? ?첸???? ?????? ?????? ??????????. ????? ???? ???? ?????? ??????? ??????? ?????????? ?????? ?쨋??? ??????. ????????? ??????? ???? ????? ?????? ??????? ????? ?????? ?刮? ???????, ????? ????? ????????. ????, ??????? ????????? ???? ????? ?????? ??耳�???? ???????, ?????? ???? ????? ?????? ?????? ????????. ????????? ?첸?????? ???????, ?????? ???? ????? ?????? ???????, ?????? ???? ???????? ????? ??????? ?????? ??? ???? ?????? ???? ???????. ????, ??????? ?첸???? ?????? ???? ?????????? ??????? ??????? ????? ?????? ?????? ???????, ??????? ??????? ??????? ?????? ?? ?? ????? ???? ??????. ?????, ?쨋??恝??? ?첸???? ??? ???? ??? ???荑�?? ??????? ?? ???? ??????. ??? ?????????? ????????? ?????? ??? ?첸?????? ?????? ???李� ???????, ????? ??? ?????? ????????? ???????? ?첸???? ????????? ????. ????, ????????? ??????? ??? ??? ?????? ????? ?? ??? ????? ?????? ???????, ?쨋??恝??? ???????? ?? ????? ????? ????? ???? ?????? ??????? ???? ?????????? ???? ????躍�???. ??????????, ??????? ?????? ???? ????? ?????? ??耳�???? ??????? ???? ?? ??? ???????? ?첸???? ????? ??????? ??????, ????????? ?????? ?????? ?? ??? ????? ????????. ??????, ????? ?????? ??? ?커? ??????? ???, ????????? ??? ????? ?????? ?????? ?? ??????? ????.
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???????? PDE5?? ??????? ????????? ??????? ???? ?? ??? ????????? PDE5?? ????????? ?????? ????? ??????? ?????? ?????????. ????? ??????? ????? ICOS?? ??????????(Galaxo Wellcome, ?????? GSK)?? ??????? PDE5?? ??????? ?????? ???????? ?????. ????? ?????? ?????? ???? ????? ???? PDE5?? ????????? ???-???????-3-????????(ethyl-carboline-3-carboxylate)?? ????????? ????, PDE5?? ???? ???? ????? ?????? ???? ?????? ????????? ???. ????? PDE5?? ???? IC50?? 5nM?? ????? ?????? ????????, ?? ?????? IC351???? ??????? ???????. ?? ?????? ???????????? ???????? ???? ?????? ????? PDE5 ??????????? ???? ??? ??閨????? ???? ?????????.????? ?????????? ????????? ?????? ?????? ??????觀??? ??????? ??????? ????? ??? ????, IC351?? ???? ???? ????????? ??????館? ?????? ??????? ?????, 1995?????? ??? 1???? ????????. ????? ????? ??????? ??? ?????? ?????? ?????? ???? ???????? ???? ??????? ??????? ????? ?????????, ICOS?? ?????? ?????? ?????? 1996?? ??????? ?????. ICOS?? ???? ???恝? ??????? ????(Eli Lilly)?? ?????? ???? ICOS(Lilly ICOS)???? ????????? ?????? IC351?? ??????? ??????館??? ??? ?????? ??????? ?????. 2002?? ????? ??? ?????????????(AmericanUrological Association)???? ???? ??????(Tadalafil)????? ???龜????? ????? ?? ???? ????????? ????????. ????? ???? ???? ???????? ???? ?? 36?챨? ???커??? ????? ???????? ????????, ?? ?????? ???????? ????????? ??????? 17.5?챨????館? ????????? 4?챨??? ????? 4?? ??? ???? ?????????. 2003?? FDA?? ???????? ???? ?????????, ???????? ???첸????(Cialis)?????? ????????? ????? ?????????. ????? ?????? ?첸???? ??? ???? ?????????????? 2016?? ???? 43?? ??? ????? ?????? ???? ????? ???? ???恝? ???? ?????? ?????? ?????. ???? ???? ?????? ??? ????肉�?? ????? ???? ????? ???? ????????? ?????? ????? ??? ????? ????????? ?????? ??? ?????? ????? ?????? ????????? ??????? ??? ???? ???????? ?? ??????? ???. ???? ????? ???????? ???? ???????? ?????? ?????? ?????? ??????? ???? ?????????? ?????? ??? ???????? ??????? ???.??????館? ???? ????? ?????? ??????觀??? ??????? ???? ?????? ???? ???? ?????? ??????? ??????? ????? ?????? ????? ?? ????? ???? ???玲� ???? ???? ??????? ???. ???? ?????? ?管??? ???????? ?????? ??? ??????????? ?????? ???玲� ???? ???? ????? ????????? ???.
?첸?????? ???
?첸?????? 1998?? ??????? ??????? ??? ????? ????, ?? ?????????? ???? ???????? ?慣? ?????????. ??? ???玲�???? ?첸?????? ???? ???? ?????????????? ????.
?첸?????? ??? ???????? ??, ??????? ??????關??? ????? ??? ?? ????? ?????? ?????? ???? ?? ?????????? ? ????? ???????. ?????? ?????? ?????? ?????????? ???????? ???? ?? ?????????? ?慣? ??? ??? ?? ????? ???????, ???? ?????????? ? ?????? ??????. ?첸?????? ??? ????? ??, ????? ?????? ?? ?????? ? ?慣? ?????????. ???, ??? ????? ????? ?????? ?첩??? ????? ??????? ??????? ???????????. ????? ?慣??? ?酉� ?????? ???? ?????? ???????? ???? ???? ????????????. ????, ?첸???? ?????? ???? ???? ?????? ?????????? ????? ??? ????????. ????? ???????? ???? ?첸???? ?? ?????? ???? ???????? ?????? ????? ???? ???????? ??????? ????????????. ????, ?? ???????? ?慣??? ????? TV ?????? ???? ????????? ??????? ?????? ???? ????? ??觀??? ????????.
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?첸????(Tadalafil)?? ?????? ???? ?? ?????? ?筠??? ??? ??????? ??? ?????? ?????? ???? ??????? ?? ?? ???????. ???????? ??????????, ?첸?????? PDE-5 ???????? ?鈞????, ?????? ??????? ???????? ???????? ?????????. ?????, ?? ???? ????? ?????, ???? ???? ???? ???? ????? ??????. ?첸?????? 2003?? FDA?? ???琯? ???????? ??????? ???? ????? ??????. ?첸?????? ??? ?????? ?????????, ???????? ?????????? ?????? ??????? ??? ???????? ?????????. ?????, ?첸?????? ?????????? ?? ????? ?????? ??????. ???????? ???? ?? 4?챨? ???? ????? ?????????, ?첸???? ????? ??? 36?챨????? ????? ???????. ??? ?첸?????? ?????? ??????? ?챨? ?????? ??????? ?????? ????? ?????? ?? ??? ?????? ????????? ? ???????? ?館????.?????, ?첸?????? ??????? ???????? ????????. ???? ??????? ??????? ????, ????????, ?????? ???? ??????. ????, ?첸?????? ?????? ????? ????? ???????, ???逵??????? ??????? ????, ?????? ???? ??????? ?????? ????? ?? ??????. ????, ?첸?????? ??? ??????? ???????? ??? ???? ??????? ??????? ?? ??????. ?????? ???? ?? ?첸???? ?????? ???????? ???? ?? ???? ???? ?????? ?????? ???? ??????? ????????. ?????, ?? ???? ???? ???????? ???????, ???????? ????? ???????? ???? ???? ?????? ?? ??????.
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1, ?첸????(Tadalafil)?? ???????? ?????????? ??????? ?????????. ???????? ?????, ?첸?????? ????? ??? ??????? ????? ???? ?? ??? ?????? ??????. ????, ?첸?????? ????? ??? 36?챨????? ???????, ?? ???? ?챨? ???? ?????? ????? ???? ?? ??????.
2, ???????(Vardenafil)?? ???????? ?첸?????? ?????? ????? ??? ??????? ?????????. ?????????? ???? ????? ????? ??????, ?? ???? ????? ????? ???荑�?? ????????? ?????? ?? ??????.
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?첸???? ?????? ??????쨔???
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2.??????? ????
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3.?????? ????
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4.???????? ??????? ????
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5.???? ???? ??????? ????
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6.???????? ??????
?첸???? ???? ?? ???????? ??? ?筠??? ???????? ????????? ?????? ???? ?? ????? ???????? ??????????. ?? ?????? ??????? ???? ??????? ???? ???恝? ???? ??????? ????????, ????????? ?????? ????? ?? ??????. ?????, ???????? ??? ?????? ??? ???罐?, ?????? ???? ?????? ??????? ??????, ?첸?????? ??? ??????? ??????? ?耳� ??????? ??? ??????.
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