??? ?????? ??????? ????????
???γ??? (18~64??)
?? ???? ?????? ????? ???? ????? ????? ??? ??? 1???? ???? ??? ????????? ???.
?????? ?? 1~3?ð? ???? ??? ?????뷮 30mg?? ?????????. 30mg?? ????? ???????? ??? ?????? ???? ????, ??? ?????뷮?? 60mg???? ?????? ?? ???.
???????? ????? ??? ??? ???? ???? ?????? ?? ??????.
?????????? ??????? ???? ?????? ????????? ?? ????.
24?ð? ???? 1?? ????? ???????? ??????.
???????: ?????????? ??????? ???? ???????? ??????? ?????? ???? ??? ????????? ??????? ???? ???????.
???????? ???????
???? ?????? ???????? ?? ??
?? ???? ????? ??? ?? ?? ?????? ???п? ???μ??? ??? ???
?????? ???? ???????????? ????? ???? ?????
??? ?? ?????? ?????? ???
?? ???? ??? ???????? ?????? ??????[?????? ???????? ?????? ??????(SSRI), ????????-?븣????????? ?????? ??????(SNRI), ????? ???????(TCA)] ??? L-???????, ????, ???????, ??????????, ??? ?? St. John's Wort (HypericumPerforatum)?????? ???? ???????? ??????? ?? ?? ?????????? ????????? ?? ???, ???? ??? ???? ??????? ?? 14?? ????? ????????? ?? ???. ??????????, ?? ???? ???? ??? ?? 7?? ????? ??? ???? ????????? ?? ???
?????? CYP3A4 ??????(??: ?????????, ??????????, ????????, ??????????, ??????θ????, ???????, ?????????, ?????????? ??)?? ???? ???? ???
?? ???? MAO(??????λ?????) ???????? ???????? ??? ??? MAO ???????? ???? ??? ?? 14?? ????? ?????? ??????. ??? ???????, ?? ?? ??????? ?? 7?? ????? MAO ???????? ????????? ?? ???.
????/?????? ??? ????? ?????? ?????? ??? ???? ?? ???? ????????? ?? ???, ????? ?????? ?????? ??????? ???? ???? ?????? ?????? ???.
???? ?????? ??????? ???? ????? ???
????, 18?? ????? ??? ?? ????
65?? ????? ??????