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???????? ????? ???? ????? ?????(Pfizer)?? ???? ????? ?????? ??? ???? ?????????. ??????? ?????? ??? ??????? ??????????, ??? ???? ??? ??? ?????? ??????? ????? ?????? ??? ???? ??????? ????????????????. 1998?? ??? ??????(FDA)?? ???? ???琯?? ?????????? "??????"???? ????????? ??????????. ???????? ?? ?????? ???????(Sildenafil)???, ?????? ??????? ?????? ???????? ??? ????????.
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????? ??????(Viagra) ????? ??? ????????????. ???? ???????? ??????? ????? 2013?? ??????? ????????????. ??? ???? ??? ??????? ?? ???? ?????? ???? ?????? ?? ????????. ???? ??? ???? ?? ?????????? ???????? ??? ??? ???? ??????? ???? ?????怜� ??? ???? ?????? ??????????.
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?첸????(Tadalafil)?? ?????? ????(ED) ?? ??????????? ??? ??????? ??????. ?? ???? ???? ?????? 1991?????? ????? ???????, ???? ???????? ?????? ICOS Corporation?? ?? ???? ???? ???? ????????? ??????????.Icos Corporation?? 2007?? ???? ???? ??? ?????(Eli Lilly and Company)???? ???????????.
ICOS Corporation?? ????????? ?????? ??? ??????? ??? ?? ?荑�?? PDE5(?貫????? 5) ???????? ?????? ????? ?????????. ????? PDE5 ???????? ???? ????? ??????? ???????? ????????? ??橘????? ????????????? ?????貫轅�(cGMP)?? ?????? ??????????.
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