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???????? ????? ???? ????? ?????(Pfizer)?? ???? ????? ?????? ??? ???? ?????????. ??????? ?????? ??? ??????? ??????????, ??? ???? ??? ??? ?????? ??????? ????? ?????? ??? ???? ??????? ????????????????. 1998?? ??? ??????(FDA)?? ???? ???琯?? ?????????? "??????"???? ????????? ??????????. ???????? ?? ?????? ???????(Sildenafil)???, ?????? ??????? ?????? ???????? ??? ????????.
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ICOS Corporation?? ????????? ?????? ??? ??????? ??? ?? ?荑�?? PDE5(?貫????? 5) ???????? ?????? ????? ?????????. ????? PDE5 ???????? ???? ????? ??????? ???????? ????????? ??橘????? ????????????? ?????貫轅�(cGMP)?? ?????? ??????????.
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