???????????? ???? ??????????
?????????? ?? ?????
??????? ????? ?? ???????? ??????? ??????
??????????.
???? : ????????
????(????) : ????????????
????? ??? ???? : 1???? - ????? ????????
???? ??? : 18?? ????
???? : ??? ??????
???? : ????????
?? : ???
???????? : ????????????꿰 70.225mg
???????? : ???п???, ???(1-30????) ????
?????? : ????????? ???
?????뷮 : ???????μ?, 1?? 1? ?????? 1?ð? ???? ?????뷮 2550mg?? ?????????, ???쿡 ???????? ?????? 4?ð? ?????? 30?? ???? ??????? ???. ??????? ?????? ???? ?뷮?? ?????? ?? ???.
?????? ???? ????????? ?????????? ???½?? ?? ??????? ????뷮?? 25mg???? ????????? ???.
- 65?? ??? (AUC 40%????)
- ?????? (????? : 80%)
- ?????? ????? (??????????????? 30 mL/min ???? : 100%)
- CYP3A4 ??????(?????????, ??????????, ??????θ????(182 %) ??, ??????????(210 %))?? ??????? ???? ????????? ???????? ??? ?? ??????? ???????? ??????? ?? ???.
- ?????????? ??????????? ????? ???? 48?ð????? ????????????뷮???? 25 mg?? ??????? ????? ???.
????? ???? ???쿡?? ?????? ?????? ?????? ?? ??????.
- 6???? ?? ?????? ??? ???????? ???? ????
- ???????? ????? ???? ????? ????
- ????? ?????? ?? ????????? ??? ????
- ?????????? ?????? ?? ?? ??? ????? ???? ????
- ?????? ??????? ?????? ??? ????
- ???? ?????????
- ???? ????????
- ??????, ????? ???
- ?????????????
- ??????, ?????? ???
?????
????? ????? ??????? ????? ??????,
?? ?? ???? ???? ????? ???????
?????? ????? ?????? ??????, ????? ???? ?????? ??????? ??????.
????????, ??? ????????? ????
????, ?????, ??18?? ???? ??????? ?????? ?? ???????.
?????? ???? ???????? ???? ??????? ????뷮?? 25mg?? ????????.
???? ?? ??????? ??????
?????? ??? ???? ??? ???? ???????
??? ???? ??? ???? ???? ?????? ?????? ?? ?? ????
????????? ???? ??????.
?????? 50mg: ????? ??????, ??????? ??????
- ?????? 50mg????
- ????? ??? ????
- ???? ???? ?? ???? ???
- ??????? ???????
- ????? ????? ???? ????
???????? ?????? ?????? ???? ??? ???? ??????? ?? ?? ???????. ??? ?????? 50mg?? ?? ???? ??????? ?뷮????, ???? ?????? ?????? ??????.
?????? 50mg???? ???????? ???????????? ?????? ??? ???? ????? ??? ??????. ??? ??? ???? ??? ???? ????? ?????? ???? ?????? PDE-5 ??????????. 50mg?? ??????? ?뷮????, ???κ??? ???? ?????? ??? ?????? ?? ?????? ??????.
????? ??? ????: ???????? ?????? ??????? ?????????? ?????? ????????? ?????? ????. ??? ???? ???? ????? ???? ?? ????????? ??? ???????. ????? ????? ???? ??????? ??????δ? ??? ????? ??????, ???? ????? ???????.
???? ???? ?? ???? ???: ????????? ?????? ???????? ??????? ?ð????? ?? 30?к??? 1?ð? ???? ???? ??? ????????. ??翡 ?? ?? ??? ???????? ????? ??????? ????. ????, ??? ?? ??????? ???? ???? ????? ?????? ?? ???????, ???? ???¿??? ??????? ???? ???????.
??????? ???????: ?????? 50mg ???? ?? ????? ?? ??? ??????? ????????δ? ????, ???? ????, ?????? ???? ??????. ???? ????? ??????? ????? ???? ???????, ???? ?? ???????? ?????? ????? ??????? ????. ????, ???꿰 ?????? ???? ???? ???쿡?? ???? ???????? ????????? ?? ????. ??? ?????? ???? ????? ????? ?? ??? ????????.
????? ????? ???? ????: ???????? ????? ??? ????? ?????? ??????. ?????? ?????? ??? ???¿? ???? ???θ? ??????? ??????? ????? ??? ???????? ??????? ????. ????? ?????? ??? ????? ???? ?????? ?????? ?? ??????.
?????: ?????? 50mg, ??? ????, ???????, PDE-5 ??????, ?????? ????, ?????, ?????