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cGMP ???? ????:?þ?????? cGMP(??????? ??????? ???????)?? ????? ??????? ?????? ???????? ?????? ??????????. ??? ?????? ??? ?????? ????????? ???????? ?? ?????? ????.
PDE5 ????:PDE5(?λ?? ?????? ??????? ?λ? ??????? 5??)?? ?????? ????????? ???????. ?þ?????? ?? ????? ????? ??????? ?????? ???????? ?????? ????????? ?? ?????? ????.??
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????????? ?þ?????? ???? ??? 30?п??? 1?ð? ???? ????????.???? ?뷮?? ???? 10mg???, ??? ????? ??? ?Ŀ? ?????? ?? ??????.??翡 ?? ???? ??????? ???, 36?ð? ???? ????? ??????? ?????????? ?????? ????? ???????.
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?? ??????:??? ?????? ???? ???? ???? ??翡?? ????? ????. ?þ?????? ??? ?????? ?? ???????? ?? ??? ???? ???? ?? ??????, ????? ???????? ??????? ?????? ?? ??????. ????? ????? ???? ??? ???????? ???? ???θ? ????????? ????.
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?þ?????? ??????? ??????? ?θ? ??????? ??????. ??????? ??????(Tadalafil)???, PDE5 ?????? ?迭?? ??????. PDE5?? cGMP???? ?????? ??????? ????ε?, cGMP?? ???? ???? ??????? ?????? ?????? ????????? ??? ??????? ?????? ????. ?þ?????? PDE5?? ????? ??????? cGMP?? ?????? ?????, ?????????? ??? ?????? ??????? ????? ????????.
??????(???????)?? ???? ??? PDE5 ???????? ???????? ??, ?þ?????? ???? ? ?????? ???? ?ð?????. ?þ?????? ??? 36?ð????? ????? ????? ?? ???, '??? ??'????? ???????ε? ??????. ??? ?????? ?????? ???? ?δ??? ??????, ???? ????????? ??????? ??????? ????. ????, ???? ??????? ???뷮 ?þ????(5mg)?? ?????? ?????? ???? ??????? ????? ??? ?????? ????? ??????.
?þ?????? ??? ?????? ?? ?? ????? ???캸??, ???? ????? ???? ?? ??? ??????? ???????(NO)?? ?к?????. ???????? ?????? ??????????? ???? ???????? cGMP ?????? ????????. cGMP?? ???? ???? ??????? ?????? ?????? ????????, ???? ?????? ???????? ??? ????????. ?þ?????? PDE5?? ??????? cGMP?? ????? ????, cGMP?? ????? ???????? ??? ?????? ??????? ??????. ??????, ?þ?????? ???? ????? ?????? ????? ???????, ?????? ?????????? ?? ?????? ????????? ???? ?????.
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?þ???? ???????? ?뷮, ???? ???, ??? ???ο? ???? ????? ?? ??????. ????????? ??????? ??? ??????? ??信 ???? 10mg ??? 20mg?? ????????. 10mg???? ??????? ????? ???????? ???? 20mg???? ?????? ?? ??????, ????? ????? ???? ?? ??????? ????. ???? ??????? ???뷮 ?þ????(5mg)?? ??????? ?????? ???? ?????? ?????? ???? ??????? ?????? ?? ??????.
?þ?????? ?????? ?? 30?п??? 1?ð? ???? ??????? ???? ???????. ??????, ???????? ???? ?? ??????? ?????? ???? ?????? ???? ??? ??? ???? ???????. ?þ?????? ????? ?????? ???????? ?????? ?? ??????. ??????, ???? ?????? ??????? ??????? ????? ??? ????? ?? ??????? ??????? ????.
?þ???? ???? ?? ??????? ?? ???? ?????? ???????. ????, ??翡 ?? ???? ??????? ????. ????, ??? ??????? ??????? ??? ??????? ?? ????. ?????? ????? ????, ???꿰 ????(????α?????? ??)?? ???? ???? ????, ?þ???? ?????? ????????. ?þ???? ???? ?? ????? ????? ??????? ????? ??? ???¿? ???????? ?????? ????.
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?þ???? ????? ??????? ??????? ??????? ??????? ?? ???? ????? ?????? ????? ????. ????, ????? ??? ?????? ??????? ???? ???????. ??????? ??, ???? ???? ???, ?????? ?????? ??? ???? ?????? ?????? ????. ???, ???? ?????? ????? ????????? ?????? ?? ??????? ????? ???? ???????.
??????? ?????? ???????. ????????? ????????? ??? ???? ?? ???????. ??????? ??, ????, ???? ??? ???? ???? ????????? ?????? ???? ???????. ????, ????????? ????? ?????? ???? ???? ???????? ????? ??? ???????.
?þ???? ???? ????? ????? ???ø? ????? ?????? ???? ???????. ?????? ?뷮?? ???????, ??? ???? ??? ??????? ??????? ????? ?????? ?????????. ?þ???? ???? ?? ????, ???, ??? ??? ???? ??????? ????? ?? ??????. ????? ??????? ???κ? ???????, ?ð??? ?????? ?????????. ??????, ????? ?????(???????? ???, ?÷? ???? ??)?? ??????? ???? ????? ???? ???? ????.
?þ?????? ??????? ??? ??????? ????????, ??????????? ?????. ????? ??? ?????? ???????, ????????? ???????, ????? ???ø? ????? ?????? ???? ?þ???? ????? ??????? ??????? ??????? ????????.
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?þ?????? ????? ????? ????? ???? ?????? ?? ??? ????????????. ?¶??ο??? ????????? ????? ?þ?????? ??? ???? ??????? ??????? ???? ????????? ?? ????. ??? ???? ????? ???? ??? ????, ????? ??????? ????? ?? ??????.
?þ???? ????? ??? ??????? ???????? ??????? ?湮??? ?????? ???? ????. ????? ????? ??? ????, ???? ???? ?? ???? ??????, ?þ???? ?????? ???????? ???????. ????? ????, ???? ???, ??? ??? ???? ??? ??? ?????? ?? ??????.
?þ???? ?????? ?뷮, ???? ???, ??? ???? ???? ??? ?? ??????. ????????? 10mg 1???? 5,000?? ~ 10,000?? ???????, 20mg?? 10,000?? ~ 15,000?? ????????. ???뷮 ?þ????(5mg)?? ?????????? ????????. ????? ?????? ???? ??????? ???? ???????.
?þ???? ????? ??????? ?????? ?????? ???????. ????, ????? ??????? ???????. ????, ?????? ?????? ?þ?????? ???? ???°? ??????, ??? ?????? ??????? ????? ????. ???????? ?????? ?þ?????? ??? ???θ? ?????? ?????????, ????? ????? ????? ??? ?????? ??????? ????.
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?þ???? ????? ????? ??????? ??????? ????????. ??????(???????), ???????(???????) ???? ??????? ??????. ????? ?????? ???? PDE5 ?????? ?迭?? ?????, ??? ?????? ????????. ??????, ???? ?ð?, ????? ?? ??? ????? ??????. ???? ????, ???????? ??? ???? ?ð??? ???? ???, ???? ?ð??? ª?????. ????????? ???????? ?þ?????? ??? ?????? ?¡?? ?????? ??????.
??????? ??? ???? ??? ?????? ??????. ??????? ??, ????? ???, ??????? ???? ???? ??????? ??????. ???, ???? ??? ?????? ?????? ??? ???????, ???, ??? ???? ??? ???? ????? ??? ???? ?????? ?????? ?? ?? ??????. ??????, ??? ?????? ?? ??? ???? ????? ????? ?? ??????, ???????? ? ?? ??????.
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