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https://onions1.cjstkdirrnr365.top
[???] ?????? ???????
1. ???????????
???????(erectile dysfunction)???
??????? ?????? ??? ???? ???? ???????? ???? ???¸? ??????,
????????? ????? ???°? 3???? ??? ???????? ???? ??????????? ????????.
2. ??????? ??????? ????
????????? ????? ??? ????????, ?????????? ??????.
?????δ? ??????? ??? ??? ???? ???? ????
PDE-5 ???????? ?????.
???????δ? ???????? ???? ?????? Alprostadil ???? ??????.
??? ?????? ????? ???? ?? ????? ???캼?????
3. ??????? ??????? ???? -PDE 5 ??????
PDE0-5 ???????? ??????? ??? ??? 1?? ???? ??????.
????????? ???????? ????.
?? ???? ???????? ???? ?????? ????????? ????? ?????
??????? ?????? ????.
????????? ????????? ???濡 ??????? ????????? ????
??濡?? ???????? ??????? ??? guanylate cyclase?? ??????????.
?????????? cGMP???? ?????? ????? ???????
?? ?????? ???? ????? ??? ???? ?????? ?? ??? ?????.
????????? ????? ???? ?? ????κ??? ???,
?? ??????? ????? ????? ??? ??? ????????? ????? ?????????,
???? ???濡?? cGMP?? ????? PDE-5?? ???? ????????.
?????? PDE-5?? ??????? ???濡?? cGMP?? ?????? ???? ?????? ?? ???
?? ??? ?????????? ??? ?? ??? ??? ??????.
PDE-5 ?????????δ? Sildenafil(Viagra)?? ????????
???Ŀ? ?? ?????? ?????? PDE-5 ????????
Tadalafil(Cialis), Avanafil(Stendra), Vardenafil(Levitra)?? ??????????.
4. ?????? ???????
?????? ????????? ???? ???? ?????? ?????? ????????.
???? ???? ???????? ?? ?????? ???? ?????? ??????,
1?? ???????? ??? ?????? ???? ???? ???? ?????? ?? ???? ??????
???? ???????????? ???????? ???.
sildenafil?? ???????? ??? ??????? ???? ???? ???? ???????
???δ? PGE1 ???????? Alprostadil?? ??????.
?? ???? ???? ???? ???? ???????, ???? ?¾????·? ????
??????? ???? ???????? ?????? ????? ??? ????? ????????.
????, Phentolamine ???? ???? ???? ?????? ?????? ?? ??????.
??????? ????? ?????? ????: ?????? ??????
- ???????????
- ??? ??????? ????? ???
- ???????? ??? ?????? ???
- ????? ???? ?? ????????
- ????? ??? ?????? ???????
????????? ???????? ???? ?????? ?????? ???? ?? ?????, ???????? ?????? ???????? ???????? ??? ???¸? ??????. ??? ????? ???ο? ???? ????? ?? ??????, ?????? ??? ???? ?????? ?? ??????.
??????? ??????? ???? ?????? ??????, ?????? ?¡?? ????? ??????. ????????? PDE5 ??????(PDE5 inhibitors)???? ????? ?????? ???? ???????, ??????, ???????, ?þ???? ???? ???? ???????. ????? ?????? ?????? ??????? ?????????? ?????? ????????? ?????? ????. ??? ???? ??? ???????, ??????? ???? ??????? ?? ??????.
???????? ???? ?θ? ????? ??????? ????? ?? ???????. ??? ??? ?????? PDE5 ???? ??????? cGMP?? ????? ????, ?????? ??????? ??????? ???????? ?ø??? ??????. ????? ?????ν? ??? ?????????? ????. ????? ???? ?????? ?????? ????? ?????????? ??????, ????? ???? ?? ?????? ?뷮???? ??????? ????.
??????? ?????? ???? ?????? ??? ????, ???? ???? ???? ??, ????? ????? ???? ??????? ????. ??? ???????, ??????, ?索?? ???? ????????? ??? ????, ??? ??????? ??????? ?????? ???? ?? ??????? ???????? ?????? ??? ???? ???????. ????, ??? ??????? ???????? ??? ????? ??? ?????? ?? ??????? ????????????
????, ??? ??????? ???????? ??? ????? ??? ?????? ?? ??????? ?????? ?? ???????, ???? ??ħ?? ????? ?????? ???? ???????. ????? ??????? ???? ??????? ??????? ??? ?????? ??????? ???? ???????.
????? ??? ???? ???? ??????? ???? ?? ?????? ? ?????? ????. ??????? ??, ???? ???? ???, ???, ???? ???? ???????? ??????? ???????? ??? ???¸? ????????, ????????? ?????? ????? ?? ?????????. ??????? ?????? ????? ?κ?????, ?????? ????????? ?????? ????? ???????? ?????? ?? ??????.
?????: ???????, ??????, PDE5 ??????, ?????? ????, ????? ???????, ????? ????, ?????, ?????? ????, ???? ????, ????? ????