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???????? ????? ???? ????? ?????(Pfizer)?? ???? ????? ?????? ??? ???? ?????????. ??????? ?????? ??? ??????? ??????????, ??? ???? ??? ??? ?????? ??????? ????? ?????? ??? ???? ??????? ????????????????. 1998?? ??? ??????(FDA)?? ???? ???琯?? ?????????? "??????"???? ????????? ??????????. ???????? ?? ?????? ???????(Sildenafil)???, ?????? ??????? ?????? ???????? ??? ????????.
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?첸????(Tadalafil)?? ?????? ????(ED) ?? ??????????? ??? ??????? ??????. ?? ???? ???? ?????? 1991?????? ????? ???????, ???? ???????? ?????? ICOS Corporation?? ?? ???? ???? ???? ????????? ??????????.Icos Corporation?? 2007?? ???? ???? ??? ?????(Eli Lilly and Company)???? ???????????.
ICOS Corporation?? ????????? ?????? ??? ??????? ??? ?? ?荑�?? PDE5(?貫????? 5) ???????? ?????? ????? ?????????. ????? PDE5 ???????? ???? ????? ??????? ???????? ????????? ??橘????? ????????????? ?????貫轅�(cGMP)?? ?????? ??????????.
???? ICOS Corporation?? ????????? ?? ????? ?????? ???? ??? ??????? ??????????. ????? PDE5 ???????? ?????? ????? ??? ?????? ?????? ?????? ??????? ???????? ??????? ?? ???? ???? ?????????. ?? ?????, ??? ???????? ????? ?첸?????? ???????? ???????? PDE5 ?????????? ?????????, ??? ???? ??? ?????? ??????????.
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???????? ?? ?????????? ???? ???? ????? ED(???????) ????? ?? ?????, ??? ?????? ???????(sildenafil)?? ?????? ?????? ??? ???????. ???, ?첸?????? ??????(tadalafil)????? ??? ????????, ?????????? ???? ?챨? ???? ????? ?????? ?????? ????? ??????. ????? ???????? ??????? ????? ?????? ?? ?????? ???? ??????? ???? ???????.
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???????? ?첸?????? ???????? ????? ????? ???? ????? ?? ??????, ????????灌? ????? ???? ???????, ???? ??? ???酉�?? ??????? ???? ????. ???, ???? ???, ??????, ?? ??? ???? ??? ???? ????????? ??? ???荑�?? ????? ???? ?? ??????? ????. ????? ???罐??? ???????, ???觀??? ???? 30?? ?? 1?챨? ???? ????? ?????? ???????, ????? ?? ?챨? ???? ???????.
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