- ?þ?????? ??????????
- ???????? ??? ????
- ???????? ??? ?? ????
- ???? ?? ???????
?þ?????? ?????? ?????? ????, ??? ??????? ??? ?θ? ??????? ?? ?? ???????. ?? ???? ??? ?????? ???????, PDE5 ?????????? ????? ??????. PDE5 ?????????? ?????? '?????????????????? 5'?? ??????? ?????? ??????, ????? ???? ???п? ?????? ?????? ?? ???? ?????? ???? ??? ?κ????? ???? ????.
???????? ??? ?????? ?????????? ????????. ?? ?????? ??? ?????? ???? ????(NO) ?????? ????????, ?? NO?? cGMP(??? ??????? ???λ?)????? ?????? ?????? ????????? ?????? ????. cGMP ?????? ?????? ???? ?????? ?????? ???????, ??? ???? ?????? ?????? ?? ???? ?????? ???????? ???? ??? ??? ??????? ????. ????? ???? ?????? ????? ??? ?????????? ??????? ???? ????, ???? ????? ???? ???? ??? ?????? ???´?? ??????.
???????? ??? PDE5 ???????? ???? ???? ???? ?ð? ???? ????? ???????? ?????? ??????. ????????? ???? ?? 36?ð??????? ??????? ????? ?? ?? ??? '??? ???'???ε? ??????. ????? ??? ???????? ??????, ???? ????? ?????? ???? ??? ???? ??????? ??????? ????? ?? ???????, ????? ???? ?? ?????? ??????? ????. ??? ?????????? ?????? ??? ????? ??????? ????? ????? ?? ??????.
???? ?? ??????????δ?, ?°, ????? ??? ???????? ????? ???? ???? ??????? ???? ??????. ?? ??°??, ??? ???? ??? ???? ???? ???? ???????? ?????? ??????? ???? ?????? ????. ??????????, ??? ???????? ?????? ???? ?? ??????? ??, ???? ?? ??? ??????? ?÷? ?????? ?????? ?? ??????, ????? ?????? ????? ???? ???? ????? ??????? ????.
?????: ?þ????, ??????, PDE5 ??????, ???????, ?????? ????, ???? ????, cGMP, ???????, ?????, ??? ?????? ????