1.????????? ?????????? - ??????????? ??? ???????? ????? ???? ???? | ???? ????????.
2.100% ??? ???? - ???? ????????????? 100% ??? ?慣? ?????? ????? ????????.
3.?????? ???橘??? ???? - ?????? ?????? ????????첩? ???? ???????? ?? ???橘??? ??躍�???.
4.??????? - ???? 4?? ?? ??? ?? 100% ???? ???? ???????? ???? ?? ??????.
5.100% ??? ?????? - ??????? ?? 100%??? ?????? ?躍�???.
6.???? ????????! - ??????????? ???? ???????????? ??? ????? ?????? ??????? ?? ??????.
7.??? ????? ?????? - ?????? ?????? ?????? ?筠??? ?????? ?????? ???????? ???????????
8.SMS?? ??????? - SMS?? ?????? ????? ??????? ????? ?????? ??? ????????.
9.100% ??? ???? - ??????? ????? ??????? 100% ????????
10.???? ?????? - 3?? ???????? ???? ????? ???? ??????????? ??????? ??????? ??????. (???? ???? ????)
11. ???? ?????캇? - ???? ?캇? ????? ???? ??????? ??????? ???? ?????????.
??????????????????????
?????????? 2025???쨔?????????????????菅?????챨????恝????????????????????????????????????????????????????? 1520%?????????????????????
??????????|????|????????????
?????????????????耳�???貫?????????쨍???????? 100%??????????????????????????????罐?????????????
?????? 25mg??? 50mg??? 100mg????類�????????????????????????????????????????????????????
?????????酉�
1.???????????????酉�??????????
1?? 1????????? 1?챨??????????酉� 50 ?? 100 mg??????????髥�???荑�???????쩌????? 4?챨??????? 30???????????????????
??????????????????酉�????????????????
??玲�??????????????
?????????쩍?????????????????????쩍???????????????酉�?? 25 mg?????????????????
????????????????????????????????65????????????????????????????????????
???????????????????????????????????????????????????????????酉�???? 25 mg??????????????
65???????AUC 40 %??????
????????????? : 80 %??
??????????????????????????? 30 mL/min ???? : 100 %??
CYP3A4 ?????????????????????????????????????罐?????182 %????????????????210 %???????????째?????????????????????????????????????????????????????
????????????????????????????? 48?챨?????????????????酉�???? 25 mg??????????????????
2.?첸?????????????酉�?????????
?????????酉�?? 1020mg??????????髥�??????쩌???????????玲�??????????????
??????????????? 1?? 1?????
??????????????????酉�????????????????
?????????????????????쩍???????????????酉�?? 10 mg??????????첩?????????
???????????酉�??????dosage adjustments???????????????쨈??
?????????????????????????????酉�?????????????????쨈?????????????????????????酉�?? 10mg????
?榮�?????????酉�?????????????????쨈??
?첸??????????酉�?? 10mg??髥�??????쩌???????????玲�????????????????????????????????Child-Pugh Class C???????첸????????????????????????????????????????째??二�????쩍???????????????/???獒쮊enefit/risk????????????????????????hepatic impairment???????? 10mg ??????酉�????????????????
?첸?????? 18?????????????????????쩐????
3.????????????????酉�??????????
???????? 25?均??? 60??????????????酉� 10mg????????????????????????????????酉�?? 20mg??????????? 5mg???????????????????????酉�?? 1?? 1? 20mg???????????????????? 1?? 1????????????????????????????????????????????????????????????????????????CYP 3A4???????恝??????罐???????????????? 5mg??????????????????
???????65??????????????????????????????????????????????酉�?? 5mg????????????????????????????酉�?? 10mg ?? 20mg??????????????
??????????????????????????????????酉�?? 5mg??????????Child-Pugh A-B??????????????????????酉�?? 10mg ?? 20mg???????????????
???????????????????????????????????酉�????????????????????crCL<30ml/min???????????????????酉�?? 5mg????????????????????????????酉�?? 10mg ?? 20mg???????????????
?榮�?????????酉�?????????????????쨈??
???????????캇?
40???????????????????????쩐???????????????????????????慣???????????????????????????誇??????????????????????????째???????????????????????????????荑�?????????????????????????????? 10??????????????????????????째??쨀??????????????????????? 40?諛�?쨀????? 20??????????????????커????????????????????????????????????????????????????
1.??????? ????? ????? ?????? ???? ??? ??? ???? ?????????????????????? ????????? ??????? ??????? ??????????.????? ? ???????? ???? ??????? ????? ??????琯? ??????? ????????? ????????? ??? ??? ????? ?????????? ??? ???? ???? ????? ????????? ?????????? ???? ?????????? (?? ??????? ?????? ????)???????? ?????? ?????? ??????????? ???? ????????? ???? ??????? ?????????????? ??????????? ???? ??????????????????
2.???? ?????? ???? ??? ?????~??? ????????? ??????? ??????챨? ????????,?????? ???? ??? ????.. ???????? ?????? ?????? 캡???? ??????? ????? ????????????????, ????? ?????? ???????? ???? ?????????????~ ?????????~
3.??????? ?첸???? 1+1???? ??????????,
???? ????????? ??? ?? ??????..???????? 3????? ??????..^^
???? ??? ????????,???? ?????^^
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?????? ?????? ?????? ?????? ?????? ???????????? ????? ??????????? ??????. ??????????? ?????? ????? ????????. ???? ??? ??????? ????????? ????????? ???첩? ????? ?????? ????? ???? ???? ??????.
?????? ???? ?????? ?????? ?????????
????? ????????? ??? ????. ????????? ??? ????????? ?쨋??? ????????? ???? ???????? ??????? ????????? ?????? ?疫�??? ?????? ??? ?????? ??????? ???? ????. ????? ????? ???恝???????? ?????? ???? ???? ?? ?????? ?????? ?????? ???????? ?? ??? ?????? ??? ????? ??? ???? ??????. ?? ?????? ??????? ????? ???? ???? ?????????? ????? ????? ??? ????? ?????? ?????? ????????.
????? ???? ???????? ?????? ?쨋??? ????????? ??????. ?쨋??? ?????????? ??? ?쨋??? ???罐??? ?????? ????????. ?? ?????? ?????? ???????觀??? ?????? ???????? ???? ? ????? ??????. ???? ???? ????????챨? ?????? ?????? ???? ???????? ???? ???? ?????? ????????. ????? ?쨋??? ????????? ???? ? ?????? ????? ???? ??? ??????? ?????? ????? ?????? ????? ????. ????? ?????? ???????? ???? ???? ?? ?캉??? ???? ??? ?????? ??? ????.
???? ?????? ?????? ????? ????? ???恝??? ??????. ?????? ????? ????? ?째? ????????? ?????? ?????. ???罐??? ????? ????? ????? ?????? ?????????? ????? ??????? ???????. ?????? ???? ? ????? ??? ????????? ???? ???? ??????? ????. ???? ?쨋??? ????????? ??????? ??????????? ????? ???? ?????? ????? ?????? ??? ??????. ??????????? ?????? ?? ???? 100%????? ??? ??? ??? ????? ????.
??????
1.????????????????????????????????????????
?????????????????쨍??????????????????????????? PM03:00 ????????????????????????????????躍�????
2.???????첸????????????쨘????????????????????????
????챨?????첸?????????3??/???????????????????????????????????????????? 10?챨???????????鴉�??????????????챨???????????躍�????
3.?????????????????????
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