1. ???????????
???????(erectile dysfunction)???
??????? ?????? ??? ???? ???? ???????? ???? ???¸? ??????,
????????? ????? ???°? 3???? ??? ???????? ???? ??????????? ????????.
2. ??????? ??????? ????
????????? ????? ??? ????????, ?????????? ??????.
?????δ? ??????? ??? ??? ???? ???? ????
PDE-5 ???????? ?????.
???????δ? ???????? ???? ?????? Alprostadil ???? ??????.
??? ?????? ????? ???? ?? ????? ???캼?????
3. ??????? ??????? ???? -PDE 5 ??????
PDE0-5 ???????? ??????? ??? ??? 1?? ???? ??????.
????????? ???????? ????.
?? ???? ???????? ???? ?????? ????????? ????? ?????
??????? ?????? ????.
????????? ????????? ???濡 ??????? ????????? ????
??濡?? ???????? ??????? ??? guanylate cyclase?? ??????????.
?????????? cGMP???? ?????? ????? ???????
?? ?????? ???? ????? ??? ???? ?????? ?? ??? ?????.
????????? ????? ???? ?? ????κ??? ???,
?? ??????? ????? ????? ??? ??? ????????? ????? ?????????,
???? ???濡?? cGMP?? ????? PDE-5?? ???? ????????.
?????? PDE-5?? ??????? ???濡?? cGMP?? ?????? ???? ?????? ?? ???
?? ??? ?????????? ??? ?? ??? ??? ??????.
PDE-5 ?????????δ? Sildenafil(Viagra)?? ????????
???Ŀ? ?? ?????? ?????? PDE-5 ????????
Tadalafil(Cialis), Avanafil(Stendra), Vardenafil(Levitra)?? ??????????.
4. ?????? ???????
?????? ????????? ???? ???? ?????? ?????? ????????.
???? ???? ???????? ?? ?????? ???? ?????? ??????,
1?? ???????? ??? ?????? ???? ???? ???? ?????? ?? ???? ??????
???? ???????????? ???????? ???.
sildenafil?? ???????? ??? ??????? ???? ???? ???? ???????
???δ? PGE1 ???????? Alprostadil?? ??????.
?? ???? ???? ???? ???? ???????, ???? ?¾????·? ????
??????? ???? ???????? ?????? ????? ??? ????? ????????.
????, Phentolamine ???? ???? ???? ?????? ?????? ?? ??????.