48?챨? ?? ??款?19 ????????? ?????? '??? ???'????
???첸? ???? ??????? ???????? ????????
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??? ???, SARS-CoV-2 ????????? 48?챨? ??? ????????? ?????? ?????
???????? ??? ???(ivermectin)?? ??? ???? ???? ?????? ??款?19?? 48?챨? ??? ????????? ?????? ???????.
?? ??? ????? ??款?19?? ??????? SARS-CoV-2 ????????? ??????? ????? ?? '?觀????(?????? ??, in vitro)' ??嚥�?? 48?챨? ??? ?????????.
???????? ?????????(FDA) ???? ???? ??? ????? ???? ???? ?????? ????????? 5000?? ????? ?????? ??????? ???????? ???? ??????? ???? ?????? ???? ??? ????? ?????(repurposing) ??鴉�?? ???????.
?????? ?????? ??款?19 ??????, ???? ??????? ????
?? ???? ??款?19 ?????? 127?????? ??? ???? ?????? 1?????? ????? ?????????? ??款?19 ??????? ??? ?? ????????? ?? ?????? ??????? ???.
??? ???????? ????? ??????????管???, HIV ????? ?????????+????????(????? ??????), ????????? ?貫潁�?(????? ????)???? ?????? ??款?19 ??????? ????????? ???? ??款?19?? ????????? ????? ??????? ?????? ????.
??? ??? ?刮???????????(Royal Melbourne Hospital)?? ?????? ?????? ??????(Victorian Infectious Diseases Reference Laboratory) Leon Caly ???????? ???? 3?? Antiviral Research?? ???? ?????? ?????? ???????? ?????? ??款?19 ??????? ?? ???? ??????.
Caly ?????? "??? ????? ?觀???? ??嚥�?? ???????? ???????? ????? ???? ??? FDA?? ???????? ???????"?? "??? ????? ?????? 2?챨? ??? Vero-hSLAM ?????? ??????? 48?챨? ??? RNA ????????? ?? 5000?? ???? ?? ??? ?? ???? ??????? ??? ????? ?????? ??? ???"?? ??????.
??? ???????
??? ????? ????? ?????? ?????? ?????? ?? ???????. FDA ?? ????? ?????? ???????? ?????, ??(scabies), ???????(river blindness), ?劇?????, ??????, ????? ?? ???????????? ???????.
??? ????? ???????? ?????? ????????? ??????(avermectin) ?? ?瓦�?? ?????.
??? ????? 1975?? ??? ????????? Satoshi Omura ?????? ??????? ?????? ?????????????????(Merck Institute for Therapeutic Research) William C. Campbell ?????? ???????.
????? 2015?? ???????? ???????? ????? ???罐? ?類� ???????剋? ??????? ????? ?첨??.
Omura ?????? ??? ????? Streptomyces avermitilis ?????????? ????????? Campbell ?????? Omura?? ????? ???濚�?觀??? ??? ????? ???????. ??? ?? ???? ?? ??????? ?????? ???? ???????? ??????? ???????.
??? ????? ?????? ???? ?????? ???????(endectocide)??, ???? ?? ??? ??????? ?????嚥� ????? ?? ??? ????????. ???????? ???? ?????????? ?? 0.12 ????? ??????? ?? ?????? ????????? ?? 50????? ?????.
??? ??? ?? ??? ?????? ?????????
??? ????? 1981?? ??? ???????? ??????? ?????? ???????(WHO)?? ??? ???? ????(List of Essential Medicines)?? ??????. ???? ????? ???????? ???????. ???? ???????? ????, ???? ???, ???캡?, ??(lice) ?? ?????? ?????? ?? ?????????? ????? ??? ???? ???????.
???? ??? ??? ??? ?????? ?? ???? ?????????? ???(roundworm) ?? ????(whipworm)?? ??????? ???????? ?????? ??????? ???????.
??? ????? ???????? ??????? ?????? ?????????. ???? ??? ???????? ??????? ??? ???? ?????? ???????? ??? ????????? ?????? ???????? ??????? ???????? ????? ?????? ???? ???????.
???? ??? ???? ?????? ??????, ???? ???? ???????? ???? ??????? ???? ???쨈?.
???????? ??????? ??? ??????
??? ????? ?????????????, ????????, ???? ?? ??? ?????? ??????? ?? ???? ?????? ?? ???.
????? ??????? ?? ???? ????(University of Bonn) ???????? ???????? ???????? ?????????????(chikungunya virus)?? ??????? ?? ???? ?????????, ??? ??瓘???????? Brian D Foy ???????? ???????? 5?? ???? ???? ???????? ????? ??????? ??????.
캐???? ?湲�????첨?????? ???????? ?? ??? ????? ?????? ??????? ???????? ????????? ????? ???? ??????. ???? ???? ??? ??????? ???????? ??? ????? ???? ?? ?? ??????????? ??????? ??? ??????? ??? ????? ???????? ??????.
??款?19?? ?????? ??? ??????
??款?19?? SARS-CoV-2 ????????? ???? ????? ???????????캇??? SARS-CoV?? ?????? ?????? ???????.
?????? SARS-CoV ????????? IMP??/??1?? ???? ?????? ?????? ?????쨈?. IMP??/??1?? SARS-CoV ???????캡??? ??????? ??????????? ???????????(nucleocytoplasmic shutting)?? ?????? ?? ?? ???? ?????. ??? ??????? ?????? ?? ????? ??????? ??? ?????? ??? ?? ???? ???? ??????.
?????? ??? ????? ???????????(nuclear transport inhibitory activity) ????? SARS-CoV-2?? ??????? ?? ???? Caly ???????? ???????. ??? ????? ?????? ???? ??????? ?????(nuclear import) ?? HIV-1 ?????? ??????? ?????? ??琯??.
???????? ??款?19 ?????????? ?????? Australia/VIC01/2020 ??????? vERO/Hslam ?????? ????????? ?????????. ???? ??? ????? ???????.
?? ????, ??? ????? ?????? ?????? ?????? 24?챨? ??? RNA ????????? 93% ???????. ?? ?????????? ????????? 99.8% ???? ?????? ???????.
48?챨??? ?????? ???????? ???? ??? ??? ????? RNA ????????? 5000?? ?????. 72?챨? ?? ????????? ?? ??? ???????? ????. ?????? ?????? ???? ?????? ???????.
???????? "??? RNA ????????? ??????? IMP??/??1 ????? ???? ?????(nuclear import)??? ??????? ??????? ?????????館? ???????? ??????? ?? ???? ?????? ??????"?? ?????.
????? ?? ????????
??? ????? ??? ?????? ???????? ???????? ??恝? ??? ?? ???. ?酉�?? ?????? ?????? ???? ??????? ???? ???캡??? ???? ?????????? ???? ??????? ?????? ???? ????????? ??? ?? ???.
???? ???? ??????? ??????, ????????, ?? ??????, ????????, ?????? ?????????, ???? ???? ???.
???? ?????????????? ??? ????? ???????? ???????? ??? "????????? ???????? ???? ???????? ???? ??????? ???????? ??????? ?? ??? ?????? ??????"?? ??????.
